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KMID : 0604220060130030091
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Korean Journal Investigative Dermatology
2006 Volume.13 No. 3 p.91 ~ p.98
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The Stromal Change of Syringoma on Eyelids
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Kwon In-Ho
Lee Dong-Hoon
An Jee-Soo
Cho Kwang-Hyun
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Abstract
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Syringoma are common benign cutaneous neoplasms demonstrating sweat gland differentiation, and usually found around the upper dermis as multiple cords or small ducts lined by epitheliums. Stromal fibrosis of syringoma is found uniquely unlike other appendageal tumors. The aim of this study is to investigate the stromal change of syringoma on eyelids. We reviewed the disease duration of 26 cases of syringoma and performed H&E stain, Masson trichrome stain, Victoria blue stain, and immunoperoxidase staining using monoclonal antibody to tryptase protein for these cases. Correlation analyses were performed to find relationships between disease duration and stromal fibrosis in H&E stain, and those among stromal fibrosis in H&E stain, elastic fiber loss in Victoria blue stain, and tryptase-positive mast cell density. Statistical analysis showed no correlation between the grade of stromal fibrosis and the disease duration in syringoma(p=0.317). However, the grades of stromal fibrosis and elastic fiber loss, the grade of stromal fibrosis and tryptase-positive mast cell density, and the grade of elastic fiber loss and tryptase-positive mast cell density were all positively correlated with statistical significance(p=0.001). In conclusion, it is suggested that stromal fibrosis of syringoma is related to elastic fiber loss and mast cell infiltration.
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KEYWORD
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Syringoma, Fibrosis, Elastic fiber, Mast cell
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